摘要
四甲基吡嗪经溴代和酯化反应得到2,3,5-三乙酰氧甲基-6-甲基吡嗪(4)和2,3,5,6-四乙酰氧甲基吡嗪(5);4和5分别经水解得2,3,5-三羟甲基-6-甲基吡嗪和2,3,5,6-四羟甲基吡嗪。其结构经UV,1H NMR,13C NMR,IR和MS表征。
2,3,5-triacetoxymethyl-6-methylpyrazine and 2,3,5,6-tetracetoxymethylpyrazine were synthesized from tetramethylpyrazine by bromination and esterification, then were hydrolyzed into 2,3,5-trihydroxymethyl-6-methylpyrazine and 2,3,5,6-tetrahydroxymethylpyrazine. The structures were confirmed by UV, 1^H NMR, 13^C NMR, IR and MS.
出处
《合成化学》
CAS
CSCD
北大核心
2010年第2期251-253,共3页
Chinese Journal of Synthetic Chemistry
基金
江苏省自然科学基金资助项目(BK2008454)
南京中医药大学科技创新风险基金资助项目(CX200802)
关键词
四甲基吡嗪
2
3
5-三乙酰氧甲基-6-甲基吡嗪
2
3
5
6-四乙酰氧甲基吡嗪
2
3
5-三羟甲基-6-甲基吡嗪
2
3
5
6-四羟甲基吡嗪
合成
tetramethylpyrazine
2,3,5-triaeetoxymethyl-6-methylpyrazine
2,3,5,6-tetracetoxymeth- ylpyrazine
2,3,5-trihydroxymethyl-6-methylpyrazine
2,3,5,6-tetrahydroxymethylpyrazine
synthesis
