bcl-2、p53蛋白在肺癌中的表达

Expression of bcl 2,p53 protein in lung cancer

目的：探讨ｂｃｌ－２和ｐ５３蛋白的异常表达与肺癌临床病理因素之间的关系。方法：应用免疫组化方法检测了术后随访５年以上的１２９例肺癌标本中ｂｃｌ－２、ｐ５３蛋白的表达。结果：ｂｃｌ－２及ｐ５３蛋白在肺癌中的阳性表达率分别为２８．７％和５２．７％，两种蛋白表达间呈显著正相关关系。在不同组织学类型中，两种蛋白阳性表达率间无显著差异。淋巴结癌转移阳性组中ｂｃｌ－２蛋白阳性表达率显著高于淋巴结转移阴性组（Ｐ＜０．０５）；而ｐ５３蛋白表达与淋巴结有无癌转移无关。ｂｃｌ－２、ｐ５３蛋白阳性表达者预后显著差于阴性表达者（Ｐ＜０．０１）。ｂｃｌ－２和ｐ５３两种蛋白均阳性表达者的预后及淋巴结癌转移能力与单种蛋白表达阳性及两种蛋白均阴性表达者的差异有显著性（Ｐ＜０．０１）。结论：ｂｃｌ－２和ｐ５３蛋白的异常表达与肺癌的生物学行为密切相关。

Purpose To study the relationship between expressions of bcl 2, p53 proteins and clinical pathological factors of lung cancer. Methods Experssions of bcl 2 and p53 proteins were detected with immunohistochemistry in 129 cases of lung cancer. Results Positivity rates of bcl 2, p53 protein were 28 7% and 52 7%, respectively; and there was positive correlation between the two protein expression but these expression were not correlated with histological types, bcl 2 expression was correlated with lymph node metastasis, but p53 expression was not. The prognosis of patients who have bcl 2 or p53 positive expression were poor. The lymph node metastasis and prognosis of patients with both bcl 2 and p53 positive were more poor than those with only one protein positive or both negative expression. Conclusion Expressions of bcl 2 and p53 proteins are correlated with the malignant progression of lung cancer and have important effect on predicting the prognosis of lung cancer patients.