我院2006～2008年病原菌分布及其耐药性结果分析

Distribution and Drug Resistance of Pathogenic Bacteria Causing Hospital Nosocomial Infection Between 2006 and 2008 in Our Hospital

目的了解病原菌的变迁和耐药性,指导抗菌药物合理使用。方法回顾性分析2006～2008年的病原菌及其耐药性。结果3632株病原菌中革兰阴性菌1813株占50%、革兰阳性菌473株占13%、真菌1346株占37%。3年来,医院感染病原菌G-杆菌增加,G+球菌不变,真菌感染有逐年降低趋势。位于前3位的革兰阴性菌和革兰阳性菌分别是大肠埃希菌、铜绿假单胞菌、鲍曼不动杆菌和金黄色葡萄球菌、凝固酶阴性葡萄球菌、屎肠球菌。碳青酶烯类仍是对革兰阴性菌抗菌作用最强的一类抗菌药物。未发现耐万古霉素的葡萄球菌和屎肠球菌。结论加强病原菌的感染监控,及时提供医院感染菌株流行情况及其耐药率变迁信息。为合理使用抗菌药物提供依据。

Objective To observe bacterial changing-pattern and drug-resistant pattern for reasonable application of antibiotics. Methods We reviewed the data of 2006 - 2008 pathogens tests. Results Of 3632 isolated pathogens, 1813 （50%）were Gram-negative bacilli ,473 （ 13 % ） were Gram-positive cocci and 1346 （ 37 % ） were fungi. Over the 3 years, Gram-negative bacilfiin strains causing hospital nosocomial infections increased, Gram-positive cocci strains remain stable, but fungous infection showed a decline tendency. The most common Gram-negative bacilli were Escherichia coli, Pscudolnonas aeruginosa and Aeinetobactcr baumannii. While the most common Gram-positive cocci were S. aureus, methicillin-resistant coagulase-negative Staphylococcus. and Enterococcus faccium. Carbapencms were the most active antibiotics tested against Gram-negative organisms. Neither strains of Staphylococcus nor strains of Enterococcus faecium were found resistant to vancomycin. Conelusions Intensification of monitoring pathogens causing hospital nosocomial will give information about bacterial prevalence and changing - pattern, which therefore will provide scientific basis for use of antibiotics.