通心络胶囊对颈动脉粥样硬化斑块的影响

Effects of Tongxinluo capsule on atherosclerotic plaques in carotid artery

目的观察通心络胶囊对颈动脉粥样硬化斑块的治疗作用及其对心脑血管事件的影响。方法符合入选标准的200例颈动脉粥样硬化斑块患者随机分为治疗组(100例)和对照组(100例)。治疗组予通心络胶囊4粒口服,每日3次;对照组予阿司匹林75 mg口服,每日1次,治疗期为1年。2组均随访1年,在治疗初始和随访1年时行彩色多普勒超声检查颈动脉内径、血流阻力、斑块稳定性与颈动脉狭窄率,对疗效进行评价并记录心脑血管事件。结果(1)2组患者性别、年龄及斑块等方面比较,差异无统计学意义(P>0.05);(2)治疗后颈动脉内径、血流阻力、斑块稳定性、颈动脉狭窄率及斑块积分等方面比较,治疗组均优于对照组,差异有统计学意义(P<0.05)。(3)治疗组患者的心脑血管事件少于对照组(P<0.05)。结论通心络胶囊能有效地干预颈动脉粥样硬化斑块的发生发展并减少心脑血管事件的发生。

Objective To investigate the therapeutic effects of Tongxinluo capsule on the atherosclerotic plaque in, the carotid after＇. Methods Totally 200 patients with atherosclerotic plaque were randomly divided into two groups, the treatment group （100 cases） was treated with Tongxinluo capsule （4 tablets once, three times a day） ,and control group （ 100 cases） was treated with aspirin （75 mg once, once a day）. All patients would be follow up for one year and carotid artery detection was carried with color Doppler at the beginning and ending respectively. Carotid artery inner diameter, resistent index, plaque stability and stenosis rate were detected, plaque score would be evaluated and stroke events were recorded. Results （ 1 ） There was no significant difference in the risk factors of the age and sex between the two groups （ P 〉 0.05）. （2） There were better therapeutic effects in Tongxinluo capsule treatment group than control group, included the carotid artery inner diameter, resistent index, plaque stability, stenosis rate and plaque score （ P 〈 0.05）. （3） The treatment group had less stoke events than that in the control group（ P 〈 0.05 ）. Conclusion It proved that the Tongxinluo capsule could intervene effectively the development of the carotid atheroselerotic plaque and reduce the incidence of cardiac and cerebral events.