肺灌注显像联合脂蛋白a对兔肺栓塞早期诊断的应用价值

Lung Perfusion Scanning Combining Lpa on Rabbit Value in Early Diagnosis of Pulmonary Embolism

目的探讨肺灌注显像及脂蛋白a(Lpa)对早期肺栓塞的诊断价值。方法家兔30只随机分为对照组和肺血栓栓塞症(PTE)组,每组15只,通过颈静脉注入自体血凝块,建立家兔急性PTE模型,分别于栓塞前后不同时段抽血检测Lpa及栓塞后行肺灌注显像,同时做肺脏解剖及病理研究PTE后血栓形成及其分布规律。结果解剖肺脏PTE组均可见肺动脉内血栓栓塞,肺灌注显像阳性诊断率达72.96%。Lpa于栓塞后24 h明显升高,与对照组比较有显著差异(P<0.05),其阳性率达86%,二者联合使肺栓塞的诊断率达94%。结论肺灌注显像联合Lpa对肺栓塞早期诊断具有重要意义,可以作为肺栓塞早期诊断的检测手段。

Objective To discuss the value of pulmonary perfusion imaging and plasma lipoprotein a（Lpa） in early diagnosis of pulmonary embolism. Methods 30 rabbits were randomly divided into control and PTE groups,15 rabbits each,through the jugular vein injection of autologous blood clots,establishing rabbit model of acute PTE,respectively,at different times before and after embolization Lpa blood test and embolization across perfusion lung scanning,while making anatomic and pathologic study of thrombosis and its distribution following PTE. Results The anatomy of the lungs in PTE groups were seen to have pulmonary embolism.The positive diagnostic rate of lung infusion imaging came to 72.96%.Lpa at 24th hour after embolization began to increase,compared with the control group,were significantly different（P〈0.05）.Perfusion lung scanning rate of positive diagnosis reached 86%. Conclusion The perfusion lung scanning combining LPa on the importance of early diagnosis of pulmonary embolism can be used as detection means in early diagnosis of pulmonary embolism.