2-[1-(2-吡啶)乙氧基]乙酸2-取代乙酯类化合物的合成及其对小鼠记忆力的影响

Synthesis of 2-substituted ethyl 2-[1-(pyridine-2-yl)ethoxy] acetate and its effects for ability of memory in mice

[目的]合成2-[1-（2-吡啶）乙氧基]乙酸2-取代乙酯类化合物,探讨其对小鼠记忆力的影响.[方法]以2-乙基吡啶为原料,经过Whol-Ziegler反应及Williamson反应及酯化反应,得到2-[1-（2-吡啶）乙氧基]乙酸2-取代乙酯（5~7）.采用水迷宫法检测对小鼠记忆力的影响.[结果]成功地合成化合物5~7,而2-[1-（2-吡啶）乙氧基]乙酸2-（1-吗啉）乙酯（5）具有提高小鼠记忆力的作用.

OBJECTIVE To synthesize the compounds of 2-substituted ethyl 2-[1-（pyridine-2-yl）ethoxy] acetate and study its effects for ability of memory in mice.METHODSThe compounds of 2-substituted ethyl 2-[1-（pyridine-2-yl）ethoxy] acetate（5~7） were prepared by using 2-ethylpyridine,through Whol-Ziegler reaction,Williamson reaction and esterification reaction,and its effects for ability of memory in mice were studied by swimming maze test.RESULTSThe 2-morpholinoethyl 2-（1-（pyridin-2-yl）ethoxy） acetate（5） has the effect of improving the ability of memory in mice.