白细胞、血脂水平与癌症的相关性

Correlativity between the levels of white blood cell and blood lipid with cancer

[目的]探讨癌症与白细胞及血脂水平的相关性.[方法]采用1∶1病例对照研究法,病例组选取癌症患者,对照组选择社区健康人群中与病例组性别和年龄匹配者.比较分析病例组及对照组的白细胞和血脂水平,并分析其与癌症的相关性.[结果]病例组患者血清甘油三酯（TG）、极低密度脂蛋白（VLDL）水平和白细胞计数（WBC）均明显高于对照组,而血浆高密度脂蛋白（HDL）水平显著低于对照组;两组总胆固醇（TC）和低密度脂蛋白（LDL）水平间无显著性差异.TG,VLDL,HDL,WBC的上四分位数与下四分位数相比较,患癌症的相对危险度分别为3.347（95%CI：1.657~6.758）,3.628（95%CI：1.741~7.557）,0.022（95%CI：0.008~0.058）,2.584（95%CI：1.320~5.059）,其余血脂指标的相对危险度无统计学意义.WBC与TG,VLDL呈正相关,与HDL呈负相关.[结论]白细胞、血脂与癌症具有一定的相关性,其中WBC,TG,VLDL是癌症发生的可疑危险因素,HDL是保护因素.

OBJECTIVE To evaluate the correlation between cancer and levels of blood lipid as well as white blood cell（WBC）.METHODSUsing 1 to 1 case control study,cancer patients in cancer group and sex,age matched health people in control group were selected,and the WBC count and level of blood lipid were compared in both group and the correlation with cancer was analyzed.RESULTSThe levels of plasma triglyceride（TG）,VLDL and WBC count were higher in cancer group than in control group,and the level of plasma HDL was lower in cancer group than in control group,and there was no significant difference in total cholesterol（TC） and LDL between 2 groups.As compared the upper quartile of TG,VLDL,HDL,WBC with the lower quartile,the Odds ratio of cancer patients was 3.347（95% CI：1.657～6.758）,3.628（95% CI：1.741～7.557）,0.022（95% CI：0.008～0.058） and 2.584（95% CI：1.320～5.059）,respectively,and there was no significant difference in the other abnormal item of blood lipid.WBC was positively correlated with TG and VLDL,and negatively correlated with HDL.CONCLUSIONCancer is correlated with WBC and blood lipid,and WBC,TG and VLDL are doubtful risk factors of cancer and HDL was a protective factor of cancer.