恢复性睡眠影响执行功能的事件相关电位研究

Effect of sleep recovery on the executive function of the brain:an ERP study

目的应用事件相关电位技术探讨8h恢复性睡眠对36h完全睡眠剥夺后大脑执行功能的影响。方法13名健康男性大学生参加正常睡眠和36h睡眠剥夺两次试验,睡眠剥夺后受试者接受8h恢复性睡眠。每次试验中受试者共接受6次Go/Nogo测验,同时记录行为学及ERP数据。结果正常睡眠时,受试者的行为学及ERP指标在各个时间点上均无统计学差异。36h睡眠剥夺后,行为学指标与基线值相比有统计学差异;Fz电极Nogo-N2、Nogo-P3及Cz电极Nogo-P3的波幅、潜伏期与基线值相比有统计学差异。8h恢复性睡眠后,平均正确反应时、Go正确反应率与36h睡眠剥夺值相比有统计学差异;Fz电极Nogo-N2、Nogo-P3及Cz电极Nogo-P3的波幅与基线值相比无统计学差异,但与36h睡眠剥夺值相比[(-6.80±3.95)与(-3.37±2.63)μV,(10.63±6.62)与(5.63±5.45)μV,(9.49±7.37)与(6.08±6.56)μV]有统计学差异;其潜伏期与基线值的差异[(254.14±15.55)与(243.08±13.97)ms,(382.14±41.07)与(349.17±30.36)ms,(369.86±26.48)与(347.48±29.24)ms]有统计学意义。结论睡眠剥夺损害了大脑的执行功能,这种损害随剥夺时间的延长而加重。8h恢复性睡眠可以使大脑的执行功能得到部分恢复,但并不能恢复至基线水平。

Objective To explore the effect of recovery sleep on the executive function after 36 h of total sleep deprivation by event related potential technology.Methods Thirteen healthy male college students participated in two trials.At the first trial normal sleep as control was investigated.At the second trial participants experienced 36 h of sleep deprivation and then accepted 8 h recovery sleep.In each trial six Go/Nogo tests were employed to test the executive control function and the ERP data were recorded.Results There was no statistical difference in behavior and ERP results at each time point as the subjects had normal sleep.After 36 h of sleep deprivation,the behavior results were statistically significant when compared to the baseline.The amplitude and latency of Nogo-N2,Nogo-P3 on Fz electrode,the amplitude and latency of Nogo-P3 on Cz electrode showed statistical significance when compared to the baseline.After 8 h recovery sleep,the average correct reaction time and the Go correct reaction rate had statistical significance compared to 36 h value.The amplitude of Nogo-N2 and Nogo-P3 had no statistical significance compared to the baseline.However,it was of statistical significance[（-6.80 3.95）vs（-3.37 2.63）μV,（10.63±6.62）vs（5.63±5.45）μV,（9.49±7.37）vs（6.08±6.56）μV] compared to 36 h value.The latency of the recovery value of Nogo-N2 and Nogo-P3 was statistically significant[（254.14±15.55）vs（243.08±13.97）ms（382.14±41.07）vs（349.17±30.36）ms,（369.86±26.48）vs（347.48±29.24）ms]compared to the baseline.Conclusion As the time of sleep deprivation is prolonged,the executive function is impaired and the executive function is not completely recovered after 8 h recovery sleep.