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COX-1在卵巢癌组织中的表达及其意义 被引量：1

Expression of cyclooxygenase-1 in ovarian cancer and its significance
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摘要 目的探讨环氧化酶-1(COX-1)在卵巢癌组织中的表达及其意义。方法应用免疫组化SP法检测37例卵巢癌和31例卵巢囊肿组织中COX-1和CA125蛋白的表达;应用ELISA法检测40例卵巢癌和31例卵巢囊肿以及60例正常体检者血清中COX-1和CA125的浓度。结果COX-1、CA125在卵巢癌组织的表达率分别为78%和57%,在卵巢囊肿的阳性表达率仅为7%和3%;卵巢癌患者血清COX-1、CA125的阳性率分别为65%和93%。结论COX-1蛋白表达可作为卵巢癌的辅助诊断指标。 Objective To explore the expression of cyclooxygenase-1 in ovarian cancer and its significance.Methods Expression of COX-1 and CA125 was detected by immunohistochemistry in 37 cases of ovarian cancer and 31 cases of ovarian cyst.The serum level of COX-1 and CA125 was tested in 40 cases of ovarian cancer and 31 cases of ovarian cyst and 60 healthy volunteers by ELISA.Results The positive expression of COX-1 and CA125 was 78% and 57% in ovarian cancer and 3% and 7% in ovarian cyst,respectively.The expression of COX-1 and CA125 was 65% and 93% at the serum level.Conclusion Expression of COX-1 could act as an auxiliary diagnostic criterion in ovarian carcinoma.
作者 吴琼 卞丽红 胡晨明 杨瑛 李亚里
机构地区 解放军 解放军总医院妇产科
出处 《军事医学科学院院刊》 CSCD 北大核心 2010年第1期58-60,共3页 Bulletin of the Academy of Military Medical Sciences
关键词 COX-1 卵巢癌 蛋白表达 cyclooxygenase-1 ovarian cancer protein expression
分类号 R737.31 [医药卫生—肿瘤]
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参考文献16

  • 1吴琼,佟雅丽,黄长江,李春海,卞丽红,向军琳.环氧化酶-1在妇科恶性肿瘤诊断中的作用研究[J].中国妇产科临床杂志,2003,4(5):373-375. 被引量：2
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二级参考文献10

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  • 10刘珊玲,彭芝兰,何斌,唐茜萍,王平,王和.血清CA19-9联合CA125检测在卵巢肿瘤中的应用价值[J].四川肿瘤防治,2001,14(2):81-83. 被引量：8

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军事医学科学院院刊
2010年 第1期

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