白英的化学成分研究

Chemical constituents from Solanum lyratum Thunb

目的对中药白英(Solanum lyratum Thunb.)全草的60%乙醇提取物进行化学研究。方法采用正相硅胶柱色谱、Sephadex LH-20凝胶柱色谱及制备薄层等方法进行分离纯化,通过波谱解析和理化鉴别进行结构鉴定。结果分离鉴定了11个化合物,包括6个异黄酮类,3个苯甲酸类衍生物、1个三萜和1个单糖苷,鉴定为:芒柄花苷(ononin,1)、染料木苷(genistin,2)、5-羟基芒柄花苷(5-hydroxyl ononin,3)、芒柄花素(formononetin,4)、大豆素(daidzein,5)、大豆苷(daidzin,6)、对羟基苯甲酸(4-hydroxy-benzaldehyde,7)、香草酸(vanillic acid,8)、原儿茶酸(protocatechuic acid,9)、阿拉伯呋喃糖苷乙酯(ethyl-α-D-arabinofuranoside,10)、熊果酸(ursolicacid,11)。结论化合物1、2、3、10、11为首次从该植物中分离得到。

Objective To investigate the chemical constituents of the 60% alcohol extract of Solanum lyratum Thunb..Method The compounds were isolated by column chromatography over silica gel and Sephadex LH-20 and preparative TLC.Their structures were elucidated on the basis of physicochemical property and spectral data.Resulut Eleven compounds were isolated and identified as：ononin（1）,genistin（2）,5-hydroxyl ononin（3）,formononetin（4）,daidzein（5）,daidzin（6）,4-hydroxy-benzaldehyde（7）,vanillic acid（8）,protocatechuic acid（9）,ethyl-α-D-arabinofuranoside（10） and ursolic acid（11）.Conclusion Compounds 1,2,3,10 and 11 are isolated from S.lyratum for the first time.