VicRK(YycFG)双组分调节系统

VicRK(YycFG) Two-Component Regulatory System

细菌双组分调节系统,或称之为双组分信号转导系统,是细菌感应外界多变环境,维持自身存活和生长繁衍的重要感应系统.在这些调节系统中,最早发现于枯草芽孢杆菌的VicRK(YycFG)系统因与细胞存活密切相关而倍受关注.该系统存在于少数低G+C含量的革兰氏阳性菌中,包括金黄色葡萄球菌和肺炎链球菌等致病菌,高度保守.许多证据显示,VicRK(YycFG)具有调控细胞壁合成与代谢、胞膜完整、细胞分裂、脂类代谢、多糖合成与被膜形成以及细菌毒力等多种功能,参与细胞的生长、分裂与感染.该系统异常可导致细菌生活力严重下降,甚至死亡,因而成为防治该类病原菌的重要靶标.

Bacterial two-component systems,also referred to as two component signal transduction systems,are recognized as a ubiquitous mechanism ensuring the survival and prosperity of a bacterium under a wide variety of environmental conditions.Of the individual two-component regulatory systems,the VicRK（YycFG）,originally identified in Bacillus subtilis,has excited interest as essential two-component systems for cell growth,cell division and infection.The essentiality has been reported to its control of cell wall biosynthesis and metabolism,cell membrane integrity,cell division,lipid integrity,exopolysaccharide biosynthesis and biofilm formation,and virulence factor expression.Recently many studies have shown that even small change of which may cause a significant decline in cell virulence and viability,even to death.Because of these effects on essential functions and the fact that the YycFG two-component regulatory system is highly conserved in low G ＋ C gram-positive bacteria,including several major pathogens,for example Staphylococcus aureus and Streptococcus Pneumoniae,VicRK（YycFG） has been considered a hopeful potential target for anti-infective therapeutics.