经穴/经脉-脏腑相关及其机制研究的进展

Progress in the Study on the Mechanism Underlying the Correlation Between Acupoints/Meri-dians and Zangfu Organs

本文从1)穴位"活动论",2)一穴对多脏器作用的规律,3)多穴/多经对一脏的影响,4)内脏疾病在体表经穴/经脉的特异反应,5)穴位注射药物的疗效优于肌肉注射,6)针刺对内脏细胞已知的特定蛋白表达的影响,7)针刺对相关脏器全基因/全蛋白表达/磷酸化的影响,8)经穴与内脏相关联系的外周途径,9)经穴与内脏联系的中枢途径,10)国外相关研究的概况等10个方面回顾了近10年来经穴-脏腑相关研究的概况,并对该研究的意义、目前存在的问题、未来的研究思路做了初步的分析。利用系统生物学的知识和技术加强对该课题的研究,必将大大促进针灸学的发展。

In the present paper, the authors review development of studies on the mechanism underlying the correlation between acupoints/ meridians and internal organs in recent 10 years from 1） doctrine of ＂dynamic acupoint＂; 2） effect of one acupoint-stimulation on multi-viscera, 3） effect of multi-acupoints/multi-meridians stimulation on one single internal organ, 4） specific reactions of visceral disorders on the body surface, 5） the therapeutic effect of acupoint-injection being better than muscular injection, 6） effect of acupuncture on the expression of some known intracellular genes/proteins of the related viscera, 7） effect of acupuncture on the expression or phosphorylation of whole genes/whole proteins of the related viscera, 8） peripheral pathways connecting acupoints and the associated internal organ, 9） central pathways connecting acupoints and the related viscera, and 10） overview of the similar researches in foreign countries. In addition, the authors also make a preliminary analysis on the research significance, current problems and the thoughts in the coming studies. Utilizing advanced knowledge and techniques of systems biology to study ＂the correlation between acupoints/meridians and internal organs＂ will greatly promote the development of acupuncturolegy.