人胚胎干细胞向内皮祖细胞诱导分化及其应用研究进展

Progress of Differentiating Human Embryonic Stem Cells Into Endothelial Progenitor Cells and Potential Applications

近年来,内皮细胞的应用价值不断提高,应用领域不断拓宽,但其来源有限,成为研究应用的主要障碍.胚胎干细胞在体外可分化为多种组织细胞系,有可能成为获取内皮细胞的另一来源.就人胚胎干细胞向内皮祖细胞分化、分离方法、相关分子机制及内皮祖细胞应用价值等进行阐述,以期能够引起更多的关注,推动其研究的进展.

Endothelial progenitor cells have great prospect for treatment of many diseases.However,derivation of endothelial progenitor cells in vitro is a major restriction for the clinical treatment.Human embryonic stem cells（hESCs） may become an alternative source of endothelial progenitor cells because of their high proliferation capability and in vitro pluripotency.Although,there are many challenges for differentiating hESCs to endothelial progenitor cells in vitro.Current understanding of this subject from recent discoveries in this field was summarized.Future work will be needed to translate these in vitro findings to clinical applications.