垂体后叶素对妇科手术患者QT间期的影响

The effect of hypophysin on QT interval of gynecology patients during surgery

目的评估在妇科腹腔镜手术中,子宫肌壁注射垂体后叶素或催产素对患者QT间期的影响。方法40例行子宫肌瘤手术的患者,ASAⅠ～Ⅱ级,年龄25～45岁,术前心电图均无异常。随机分为两组:A组(垂体后叶素组,n=20),B组(催产素组,n=20)。均采用气管插管全身麻醉,分别于注射垂体后叶素或催产素前、注射后2、5、10、20、30min行心电图检查,记录血压(blood pressure,BP)、心率(heart rate,HR)、QT间期,根据公式计算心率校正后的QT间期(QTc)。结果子宫壁注射垂体后叶素2、5、10min后QT间期显著延长(P<0.01);催产素组QT间期有延长趋势,但无统计学意义(P>0.05)。结论子宫壁注射垂体后叶素使患者QT间期显著延长,在临床应用中应引起重视。

Objective To evaluate the effect of hypophysin and oxytocin on QT interval of the patients undergoing myomectomy. Methods Forty ASAⅠ-Ⅱ female patients scheduled for laparoscopic operation were enrolled. All patients were randomized into hypophysin or oxytocin group, with 20 patients in each group. The blood pressure, heart rate and QT interval were recorded at following time points： before anesthesia （T1）, before injection of hypophysin or oxytocin （T2）, 2 min （T3）, 5 min （T4）, 10 min （T5）, 20 min （T6）, and 30 min （T7） after injection of hypophysin or oxytocin. Results The QT interval at 2, 5 and 10 min post injection of hypophysin were significantly longer compared to oxytocin group （P0.01）. No significant changes of QT interval were detected in oxytocin group, though the trend of QT interval prolongation were recorded. Conclusions In hysteromyoma operation, injection of hypophysin could prolong the QT interval of patients.