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VEGF-C和LYVE-1在卵巢上皮性肿瘤中的表达及其临床意义 被引量：1

Expressions of VEGF-C and LYVE-1 in epithelial ovarian neoplasm and their clinical significance
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摘要 目的探讨血管内皮生长因子-C(VEGF-C)和淋巴管内皮透明质酸受体-1(LYVE-1)在卵巢上皮性肿瘤中的表达及其与临床病理因素之间的关系。方法免疫组织化学SP法检测61例卵巢肿瘤患者手术标本中VEGF-C及LYVE-1的表达,分析其与临床病理因素的关系。结果①VEGF-C及LYVE-1在卵巢上皮性癌中的表达均明显高于卵巢交界性肿瘤和卵巢良性肿瘤(P<0.01);②VEGF-C及LYVE-1的表达与卵巢上皮性癌患者年龄、组织学分级、组织学类型无关(P>0.05),但与临床分期、淋巴结转移相关(P<0.05)。结论VEGF-C和LYVE-1在卵巢上皮性肿瘤淋巴转移过程中发挥了重要作用。 Objective To investigate expressions of vascular endothelial growth factor-C（VEGF-C）and lymphatic vessel endothelial hyaluronan receptor-1（LYVE-1） and their relationship to the clinico-pathological factors in epithelial ovarian tumors.Methods The immunohistochemical SP method was used to detect VEGF-C and LYVE-1 expressions in 61 surgical specimens from patients with epithelial ovarian neoplasm and their relationship to clinical pathological factors was analyzed.Results ①VEGF-C and LYVE-1 expressions in epithelial ovarian carcinoma were significantly higher than those in borderline ovarian tumors and ovarian benign tumors（P〈0.01）;②VEGF-C and LYVE-1 expressions in patients with epithelial ovarian cancer were obviously related to clinical stage and lymph node metastasis（P〈0.05） while notrelated to age,histological grade and histological type（P〉0.05）.Conclusion VEGF-C plays an important role in lymphatic metastasis of epithelial ovarian tumors.
作者 柴新华 刘培淑 刘素华 杨美香
机构地区 山东大学齐鲁医院妇科 禹城市人民医院妇科
出处 《山东大学学报（医学版）》 CAS 北大核心 2010年第3期94-97,共4页 Journal of Shandong University:Health Sciences
关键词 卵巢肿瘤 淋巴转移 血管内皮生长因子-C 淋巴管内皮透明质酸受体-1 Ovarian neoplasms Lymphatic metastasis Vascular endothelial growth factor-C Lymphatic vessel endothelial hyaluronan receptor-1
分类号 R737.31 [医药卫生—肿瘤]
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参考文献12

  • 1Jackson D G. Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis [ J]. APMIS, 2004, 112 (7-8) : 526- 538.
  • 2Weidner N, Semple J P, Welch W R, et al. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma[ J]. N Engl J Med, 1991, 324( 1 ) : 1-8.
  • 3Gombos Z, Xu X, Chu C S, et al. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix [J].Clin Cancer Res, 2005, 11 ( 23 ) : 8364- 8371.
  • 4王海杰,谭玉珍.淋巴管新生及其在相关疾病发生和治疗中的意义[J].解剖学报,2007,38(2):250-252. 被引量：21
  • 5Joukov V, Pajusola K, Kaipainen A, et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 ( VEGFR-3 ) and KDR ( VEGFR-2 ) receptor tyrosine kinases [J]. EMBO J, 1996,15 ( 7 ) : 1751.
  • 6陈茂根,陈维荣,蔡高阳,庄潮平,李廷汉,廖梓群.淋巴管内皮透明质酸受体-1在直肠癌中的表达及其意义[J].中国普通外科杂志,2007,16(9):906-909. 被引量：5
  • 7Bo C, Xiaopeng D, Chuanliang P, et al. Expression of vascular endothelial growth factors C and D correlates with lymphangiogenesis and lymph node metastasis in lung adenocarcinoma[J].Thorac Cardiovasc Surg, 2009 ,57 ( 5 ) : 291-299.
  • 8Mofita H, Ishikawa Y, Akishima-Fukasawa Y,et al. Histopathological predictor for regional lymph node metastasis in gastric cancer [J]. Virchows Archiv, 2009,454 (2) :143-151.
  • 9Yokoyama Y, Chamock-Jone D S, Licene D, et al. Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma [J]. Br J Cancer, 2003, 88 (2) : 237-244.
  • 10Bolat F, Gumurdulu D, Erkanli S, et al. Masin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma[J].Pathology Research and Practice,2008,1 (6) :379-387.

二级参考文献62

共引文献25

同被引文献15

  • 1Courtine G, Song B, Roy R R, et al. Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury [ J ]. Nat Med, 2008, 14( 1 ) :69-74.
  • 2Patel C B, Cohen D M, Ahobila-Vajjula P, et al. Effect of VEGF treatment on the blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced magnetic resonance imaging [ J ]. J Neurotrauma, 2009, 26 (7) : 1005-1016.
  • 3Liu Y, Figley S, Spratt S K, et al. An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury[J]. Neurobiol Dis, 2010, 37 (2) :384-393.
  • 4Nesic O, Sundberg L M, Herrera J J, et al. Vascular endothelial growth factor and spinal cord injury pain [J]. J Neurotrauma, 2010, 27 ( 10 ) : 1793-1803.
  • 5Herrera J J, Nesic O, Narayana P A. Reduced vascular endothelial growth factor expression in contusive spinal cord injury[ J ]. J Neurotrauma, 2009, 26 (7) :995-1003.
  • 6Schoch H J, Fischer S, Marti H H. Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain [J ]. Brain, 2002, 125 ( Pt 11 ) :2549-2557.
  • 7Benton R L, Whittemore S R. VEGF165 therapy exacerbates secondary damage following spinal cord injury[J]. Neurochem Res, 2003, 28 (11 ) : 1693-1703.
  • 8Andras L, Susan C B, Robin J M, et al. Olfactory ensheathing cells induce less host astrocyte response and chondroifin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter [ J ]. Experimental Neurology, 2003, 184 ( 1 ) :237-246.
  • 9Ozawa C R, Banff A, Glazer N L, et al. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis [J]. J Clin Invest, 2004, 113(4) :516-527.
  • 10Widenfalk J, LipsonI A, Jubran M, et al. Vascular endothelial growth facter improves overcome and decreases secondary degeneration in experimental spinal cord injury[J]. Neurosci, 2003, 120(4) :951-960.

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山东大学学报（医学版）
2010年 第3期

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