生大黄纳络酮奥曲肽在肝昏迷中的治疗作用

目的观测中药生大黄、纳络酮、奥曲肽联合应用对肝昏迷的有催醒作用,肝功能的改善情况以及对近期预后的影响。方法将74例肝昏迷患者随机分为常规治疗组(对照组)37例,给予传统常规治疗。中药生大黄、纳络酮、奥曲肽联合治疗组(治疗组)37例。观测两组患者在各自治疗方法下恢复清醒的时间、不同时段内肝功能好转情况以及死亡率。结果治疗组患者恢复清醒时间、死亡率,均明显低于(或短于)对照组,治疗后肝功能的好转情况明显优于对照组,差异经统计学检验具有统计学意义(P<0.01)。结论中药生大黄、纳络酮、奥曲肽联合应用能缩短肝昏迷患者恢复清醒的时间,较好改善肝功能,降低死亡率。

Objective Observation Chinese medicine rhubarb,naloxone,octreotide combined with right hepatic coma whether the wake-up effect,as well as short-term prognosis and to monitor the changes in liver function in patients.Methods 74 cases of hepatic coma patients will be randomly divided into conventional therapy group （hereinafter referred to as control）,37 cases with conventional treatment.Chinese medicine rhubarb,naloxone,octreotide combination therapy group （hereinafter referred to as the treatment group） 37 cases.Observing the two groups in their treatment of patients to resume a sober time,mortality,and to monitor patients in both groups at different times of improvement of liver function in Results The patients had regained conscious of time,mortality rate,were signifi cantly lower （or shorter than） the control group,as well as the changes in liver function after treatment improved the situation signifi cantly better than the control group,the difference by the test have a very signifi cant （P0.01）.Conclusion Chinese medicine rhubarb,naloxone,combined with octreotide in patients with hepatic coma can shorten recovery time awake,reduced mortality rates;better to improve liver function.