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Hepatitis C virus' Achilles' heel - dependence on liverspecific microRNA miR-122 被引量:2

Hepatitis C virus' Achilles' heel - dependence on liverspecific microRNA miR-122
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摘要 Hepatitis C virus (HCV) is an important human liver pathogen that has infected over 170 million people worldwide, often leading to liver cirrhosis and hepatocellular carcinoma [1]. While the efficacies of novel inhibitors of the viral polymerase and protease enzymes are being explored in numerous clinical trials, current therapies against HCV infections are limited to a combined administration ofpegylated interferon-or and ribavirin. However, this combination therapy has considerable side effects, which include influenza-like symptoms, depression and anemia [2].
出处 《Cell Research》 SCIE CAS CSCD 2010年第3期247-249,共3页 细胞研究(英文版)
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参考文献14

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同被引文献35

  • 1Laxton, et al. Selection, Optimization, and pharmacokinetic properties of a novel, potent antiviral locked nucleic acid-based antisense oligomer targeting hepatitis C virus internal ribosome entry site [J]. Antimicrob Agents Chemother, 2011, 55(7):3105-3114.
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  • 7Lanford R E, Hildebrandt Eriksen E S, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection [J]. Science, 2010, 327:198-201.
  • 8Andrea D Branch, Charles M Rice. Antisense gets a grip on miR-122 in Chimpanzees [J]. Sci Transl Med, 2010, 6: 2(13):13psl.
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