摘要
目的:评价血清CA15-3水平及其倍增时间(DT)对18F-FDG SPECT/CT探测乳腺癌患者术后复发及转移的影响。方法:对43例乳腺癌术后患者进行18F-FDG SPECT/CT显像,每位患者均接受>2次的血清肿瘤标志CA15-3测定,并计算其倍增时间。结果:根据病理检查结果或>1年的临床随访,43例患者中有21例最终诊断为复发或转移。按患者例数计算,18F-FDG SPECT/CT的灵敏度、特异度、准确度、阳性预测值和阴性预测值分别为86%、64%、74%、69%和82%。18F-FDG SPECT/CT显像阳性患者的血清CA15-3水平高于18F-FDGSPECT/CT显像阴性患者,结果差异有统计学意义,P<0.05;0 d<DT<180 d的患者18F-FDG SPECT/CT阳性率比阴性率高,两者差异有统计学意义,P<0.05;DT>180 d及DT<0的患者18F-FDG SPECT/CT阳性率与阴性率差异无统计学意义,P>0.05。结论:对于血清CA15-3水平升高或其倍增时间较短的乳腺癌术后患者,进行18F-FDG SPECT/CT显像探测复发或转移的价值更大。
OBJECTIVE：To evaluate the influence of serum CA15-3 level and doubling time on detection of 18^F-FDG SPECT/CT for breast cancer patients with occult recurrence and metastses.METHODS：18^F-FDG SPECT/CT was performed in 43 patients with suspected recurrent breast cancer,the elevated serum CA15-3 level was deteeted for more than 2 times,and the doubling time was accounted.RESULTS：Among the 43 patients,the final diagnosis of recurrence or metastses was established in 21 patients according to more than 1 year follow up and pathology results.On patient-based analysis,the sensitivity,specificity,accuracy,positive and negative predictive values of 18^F-FDG SPECT/CT were 86%,64%,74%,69% and 82%,respectively.The median serum CA15-3 levels were higher in the positive 18^F-FDG SPECT/CT group than those in the negative group（P〈0.05）.The likelihood of depicting recurrence or metastases was higher in patients with a shorter doubling time（0〈DT〈180 d,P〈0.05）.The positive and negative rates of 18^F-FDG SPECT/CT in patients（DT〉180 d and DT〈0） have no significant difference（P〉0.05）.CONCLUSION：To breast cancer patients with higher serum CA15-3 level and shorter doubling time,18^F-FDG SPECT/CT is more likely to detect the recurrence and metastses.
出处
《中华肿瘤防治杂志》
CAS
2010年第2期134-137,共4页
Chinese Journal of Cancer Prevention and Treatment
