酪氨酸激酶受体RON与非小细胞肺癌

Tyrosine kinase receptor RON and non-small cell lung cancer

目的:探讨酪氨酸激酶受体RON与非小细胞性肺癌发生的可能机制。方法:应用PubMed和CHKD期刊全文数据库检索系统,以"RON、MSP和肺癌"为关键词,检索2000-01-2009-09相关文献,共检索到英文文献130篇和中文文献17篇。精选50篇,最后纳入21篇进行归纳分析。结果:国外文献对RON有较深入的分析,论及RON在乳腺、结肠、肝、肺、肾、膀胱及卵巢肿瘤中,RON呈现过度表达,发生率波动于32.8%～59%,这取决于肿瘤的类型差异。国内对MSP/RON与肺癌发生的可能机制研究明显偏少,仅为3篇。结论:RON的过度表达与肺癌的进展、转移密切相关,检测RON的异常对判断肿瘤的临床进展及转移有一定的参考价值,RON可能成为诊断治疗的新靶点。MSP/RON在肺癌发生中的机制是极其复杂的,有待进一步的阐述。

OBJECTIVE：To discuss the possible mechanism that RON（recepteur d＇origine nantais） causes non-small cell lung cancer.METHODS：By using ＂RON,MSP and lung cancer＂ as key words the articles were searched between January 2000 and September 2009 in the PubMed and CHKD full-text database index systems and 130 documents in English and 17 documents in Chinese were found.Fifty documents were carefully chosen,and 21 documents were analyzed finally.RESULTS：RON shows over expression in the breast,colon,liver,lung,kidney,bladder and ovary cancers,and the probabilities are between 32.8% and 59%,depending on the type of the different cancers.There is only 3 documents about the possible mechanism of MSP/RON causing lung cancer in China.CONCLUSIONS：The RON＇s over expressor is related to the development and metastasis of lung cancer closely,and the detection of the abnormal phenomena of RON is of value for estimating the development and metastasis of the cancers.RON may be the new target spot of diagnosis and treatment.The mechanism that MSP/RON causes lung cancer is very complicated,and it is pending further discussion.