基因多态性与华法林剂量需求关系的研究进展

Relationship of gene polymorphisms and warfarin dosage requirement

华法林是最常应用的口服抗凝药之一。近年来关于华法林个体化用药的最大的研究进展是基于基因多态性的给药模型,以及大规模的随机对照临床试验用于评价给药模型的有效性和安全性。本文综述了与华法林剂量需求相关的药效学及药代动力学基因多态性;同时,介绍了基于基因多态性的华法林给药模型的最新进展,为临床华法林个体化用药提供参考。

Warfarin is one of the most usually prescribed oral anticoagulation. A large number of studies investigated on the relationship between gene polymorphisms and warfarin dosage requirement. Recently, geneguided warfarin dose regimens were fully investigated, and some randomized controlled clinical trials were designed to evaluate the safety and efficacy of gene - guided regimens. This article reviewed warfarin - dosage -related pharmacokinetics and pharmacodynamics gene polymorphisms, and introduced the newly published studies on dosing regimens, in order to supply some suggestion for warfarin individual dosage.