多指标综合评分法优选舒筋通络颗粒提取工艺

Applying Grading Methods of Synthesizing Multiple Guidelines to Optimize Extraction Technology for Shujintongluo Granules

目的优选舒筋通络颗粒最佳提取工艺。方法根据处方的功能主治和药物成分的性质,以芍药苷、总生物碱的含量及浸膏得率为考察指标,采用正交试验法,以多指标综合评分筛选最佳提取工艺。结果舒筋通络颗粒最佳提取工艺为加水8倍量,浸泡1.5h,提取3次,每次1.5h。结论优选的提取工艺科学、合理,适于大规模生产。

OBJECTIVE To investigate the technology of optimal extraction for Shujintongluo granules.METHODS Based on the function and indication of the formula and the properties of its chemical components,orthogonal design was employed for conducting the multiple guidelines evaluation and selecting the optimum extraction technology with paeoniflorin,total alkaloids and the yield of extraction as the detective index.RESULTS The optimal extraction technology of Shujintongluo granules was by 8 times volume of water soaking for 1.5 h,then extracting 3 times with 1.5 h for each time.CONCLUSION The optimized extraction condition is reasonable and scientific,and it could be used in future large-scaled preparation of Shujintongluo granules.