期刊文献+

静注帕瑞昔布钠对下肢手术患者静脉自控镇痛的影响 被引量:3

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摘要 非甾体类抗炎药(NSAIDS)辅助阿片类药已广泛用于术后镇痛,取得良好的效果。近年来提出了超前镇痛及平行镇痛等多模式镇痛方式,以降低单一药物的剂量和不良反应。帕瑞昔布钠是新一代的NSAIDS类药物,是第一个可静脉或肌肉注射用的选择性环氧化酶-2(COX-2)抑制剂,可抑制外周和中枢COX-2的表达,减少前列腺素的合成,抑制痛觉过敏。本研究拟在观察静脉注射帕瑞昔布钠对术后患者芬太尼自控镇痛(PCIA)的效应及不良反应,为临床应用提供参考。
出处 《浙江医学》 CAS 2010年第3期380-381,共2页 Zhejiang Medical Journal
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参考文献7

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