国内萘丁美酮治疗类风湿关节炎的疗效及安全性的Meta分析

Effect and Safety of Nabumetone in the Treatment of Rheumatoid Arthritis:A Meta-analysis

目的:系统评价国内萘丁美酮治疗类风湿关节炎的临床疗效和安全性。方法:对有关萘丁美酮治疗类风湿关节炎的疗效和不良反应研究文献进行Meta分析。结果:共有9项研究符合纳入标准。萘丁美酮治疗类风湿关节炎疗效总体优于对照组[RR=1.11,95%C(I1.02,1.20),P=0.01],不良反应发生率低于对照组[RR=0.71,95%C(I0.41,1.22),P=0.007]。结论:现有研究显示,萘丁美酮治疗类风湿关节炎疗效优于对照组,且安全性较高。但由于本研究中纳入文献在质量及数量上的局限,上述结论尚需大样本、长期随访的高质量随机对照试验进一步证实。

OBJECTIVE： To evaluate the clinical curative effect and safety of nabumetone for rheumatoid arthritis. METHODS： The researches about the study on the curative effect and ADRs of nabumetone for rheumatoid arthritis were retrieved and cartied out by Meta-analysis. RESULTS： 9 researches were up to the including criteria. As compared with the control group, nabumetone has better effect [RR=1.11,95% CI（1.02, 1.20）, P=0.01] but fewer ADRs [RR=0.71,95% CI（0.41, 1.22）, P=0.007] in clinical treatment of rheumatoid arthritis. CONCLUSION： The evidence currently available shows that nabumetone has better efficacy and safety. Because the RCTs available for this systematic review are too small, more and further high-quality large-scale RCTs with long-term follow up are required to provide more reliable evidence