高聚金葡素联合顺铂局部治疗肺癌恶性胸腔积液的疗效观察

Clinical Observation on Treatment of Malignant Hydrothorax with Locally Administered Highly Agglutinative Staphylococcin and Cisplatin

目的:观察胸腔内中心静脉导管留置引流后高聚金葡素(HAS)与顺铂治疗肺癌恶性胸腔积液的临床疗效。方法:将90例肺癌合并胸腔积液患者随机分为A、B、C3组,应用中心静脉导管胸腔穿刺置管引流,A组胸腔内注入HAS5000U,B组胸腔内注入顺铂40mg·m-2,C组胸腔内注入HAS5000U+顺铂40mg·m-2,每周1次,连用3周后进行疗效评价,并记录不良反应。结果:3组总有效率分别为43.0%、46.7%、80.0%,C组与A、B组比较差异均有统计学意义,而A、B组比较差异无统计学意义。3组不良反应比较差异无统计学意义。结论:HAS与顺铂联用局部治疗肺癌胸腔积液疗效好、毒副作用小。

OBJECTIVE： To observe the clinical efficacy of highly agglutinative staphylococcin （HAS） combined with cisplatin in the treatment of malignant hydrothorax after straining and inserting central venous catheter in thoracic cavity. METHODS： 90 patients with malignant hydrothorax combined with lung cancer were randomly divided into A,B,C 3 groups. Central venous catheter was inserted in thoracic cavity for strainage. Group A were intrapleural injected with 5 000 U HAS, group B 40 mg ·m^-2 cisplatin and group C 5 000 U HAS combined with 40 mg· m^-2 cisplatin once a week. Clinical efficacies of 3 groups were evaluated after 3 weeks of treatment. RESULTS： The total effective rate of group A, B and C were 43.0%, 46.7% and 80.0% respectively. There was obvious difference between group C and A as well as group B（P〈0.05）. There was no statistical significance between group A and B. CONCLUSION： HAS combined with cisplatin is effective in the treatment of malignant hydrothorax with mild adverse drug reaction.