左卡尼汀致癫痫大发作1例并文献分析

Analysis 1 Case of Literature on Grand Mal Epilepsy Induced by Levocarnitine and Literatures Analysis

目的:分析左卡尼汀致癫痫大发作的文献,探讨发作原因、临床特点及治疗措施,以指导临床合理用药。方法:通过中国知网及维普资讯网检索1999～2009年国内医药期刊报道的相关文献。结合我院1例注射用左卡尼汀致癫痫大发作病例综合分析左卡尼汀致癫痫大发作的原因。结果:综合文献报道及本院1例左卡尼汀致癫痫大发作共7例患者的一般资料、既往病史、给药方法及剂量、发生时间、处理及结果,所有患者均在静脉滴注左卡尼汀过程中呈典型的癫痫大发作临床表现,经积极治疗后均缓解。结论:左卡尼汀致癫痫大发作不良反应较少见,机制尚不清楚,临床须引起足够重视。

OBJECTIVE： To analyze the literatures on grand mal epilepsy caused by levocamitine,explore the causes of seizures, the clinical features and treatment measures in order to provide guidance for rational use of drug. METHODS： Included studies retrieved from CNKI and VIP in china journal of medicine from 1999-2009.Based on a grand mal epilepsy case caused by levocarnitine for Injection in our hospital, cases of grand mal epilepsy caused by levocarnitine reported in literatures were analyzed comprehensively. RESULTS： The clinical information of grand mal epilepsy cases reported in our hospital and literatures were analyzed as well as past medical history, usage and dosage, onset time, treatment method and efficacy. All patients were in the process of irrigation of Levocarnitine showed the typical clinical manifestations of grand mal epilepsy, after active treatment were both mitigation. CONCLUSION： The adverse reaction that grand mal epilepsy is caused by levocarnitine is rare, and pathogenesis is not clear but clinicians should pay attention to it.