老年高血压宽脉压与炎症、哇巴因关系的研究

Study of the relationship between high pulse presure and inflammatory factor, endogenous ouabain in elderly hypertensive patients

目的探讨炎症、内源性哇巴因(EO)在宽脉压形成中的作用。方法入选65位受试者,均为老年高血压病患者,对入选者进行药物洗脱。根据受试者24h动态平均脉压(PP)分为二组,即≥60mmHg组及<60mmHg组。测定两组患者血清白介素-6(IL-6)、高敏C反应蛋白(hs-CRP)及哇巴因(EO)。比较两组检测指标的差异。结果PP≥60mmHg组IL-6[(30.1±5.0)pg/L]、hs-CRP[(5.4±2.0)mg/L]、EO[(0.79±0.12)μg/L]均显著高于PP<60mmHg组各测量值[(20.3±3.6)pg/L、(4.2±1.2)mg/L、(0.70±0.12)μg/L,P<0.05]。结论炎症反应、EO可能参与了宽脉压的形成。

Objective To study the effects of inflammation and endogenous ouabain （EO） on the formation of high pulse press （PP）. Methods Sixty-five hypertensive patients were selected. After wash out, the subjects were divided into two groups based on the average ambulatory pulse pressure of 24h. One group included patients whose PP was equal to or higher than 60 mmHg （n=31）, the other group were patients with PP〈 60 mmHg （n=34）. The serum C-reactive protein, IL-6 and EO in all cases were measured. All the parameters before and after the therapy were compared. The data were analyzed with SPSS11.5. Results The serum levels of C-reactive protein, IL-6 and EO were significantly higher in PP≥ 60 mmHg group than that in the PP〈60 mmHg group. Conclusions Inflammation and EO are probably involved in the development of high pulse-pressure.