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心衰治疗靶点与干预研究进展 被引量:11

Progress in therapeutic targets and intervention of congestive heart failure
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摘要 随着对心衰发病、进程以及恶化病理生理过程了解的不断深入,心衰新靶点的干预正在成为治疗心衰的希望。文中综述了心肌肥厚过程中包括钙调神经磷酸酶(CaN)、G蛋白、糖原合酶激酶3(GSK3)、肌细胞增强因子2(MEF2)、过氧化物酶体增生激活受体(PPAR)、小G蛋白(smallG protein)、Na+/H+交换体(NHE)、亚细胞器(subcellular organelles)的治疗靶点,以及天冬氨酸特异性半胱氨酸蛋白酶(Caspase)、核酸内切酶、凋亡调节因子等细胞凋亡治疗靶点与干预,同时,也综述了内皮素及受体、炎性因子及贫血治疗新靶点的干预药物、干预措施及机制,为心衰治疗、新药研发提供思路。 With the understanding of pathophysiological process in pathogenesy,process,and deterioration of congestive heart failure,novel targets for intervention is becoming the hope of the treatment for heart failure.In this paper,we summarized the therapeutic targets and intervention in process of cardiac hypertrophy including calcineurin(CaN),G protein,glycogen synthase kinase-3(GSK3),myocyte enhancer factor-2(MEF2),peroxisome proliferator-activated receptor(PPAR),small G proteins(sGp),Na+/H+ exchanger(NHE),subcellular organelles,as well as targets of apoptosis,endothelin(ET) and its receptors,inflammatory factors,and anemia.The purpose is to give references in RD of new drugs on heart failure.
出处 《中国新药杂志》 CAS CSCD 北大核心 2010年第6期486-493,共8页 Chinese Journal of New Drugs
基金 国家科技支撑计划(2007BAI41B02)
关键词 心力衰竭 靶点 心肌肥厚 细胞凋亡 内皮素 炎性因子 贫血 congestive heart failure target myocardial hypertrophy apoptosis endothelin inflammatory factor anemia
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