18F-FDG PET/CT对结直肠癌术后血清CEA升高病例的临床诊断价值

Application of 18F-FDG PET/CT for investigating elevated serum CEA in post operative patients with colorectal cancer

目的探讨18F-FDG PET/CT在结直肠癌术后血清CEA升高病人中的应用。方法35例结直肠癌术后血清CEA升高的病人均进行了18F-FDG PET/CT显像,并与病理及临床随访结果进行比较。结果PET/CT诊断阳性28例,2例假阳性,阴性7例,1例假阴性。PET/CT诊断的灵敏度为96.3%,特异性为75%,阳性预测值为92.9%,阴性预测值为85.7%。结论对结直肠癌术后血清CEA升高病人应用18F-FDG PET/CT检查能够明显提高复发及转移诊断的准确性,尤其是对常规检查找不到复发或转移灶的病人价值更大。

Objective： To investigate the clinical value of 18F-FDG PET/CT for investigating elevated serum CEA in post operative patients with colorectal cancer. Methods： 18F-FDG PET/CT were performed in 35 patients with elevated CEA. PET/CT results were compared with the final histopathological and clinical follow-up findings. Results： PET/CT was positive in 28 patients and normal in 7 patients. When correlated with histopathology or radiology and clinical follow-up, PET/CT was false positive in 2 patients, false negative in 1 patient. The sensitivity, specificity, PPV, NPV of 18F-FDG PET/CT were 96. 3% ,75% ,92.9% ,85.7%. Conclusion： 18F-FDG PET/CT can significantly improve diagnostic accuracy in post operative patients with colorectal cancer.