生长抑素受体亚型SSTR2、SSTR5在人原发性肝癌组织中的表达

The expressions of somatostatin receptor subtype SSTR2 and SSTR5 in human hepatocellular carcinoma

目的研究生长抑素受体亚型SSTR2和SSTR5在人原发性肝癌组织中的表达情况。方法应用免疫组织化学方法分别检测25例原发性肝癌组织和14例癌旁肝硬化组织SSTR2、SSTR5的表达。结果18例(72%)肝癌组织至少表达一种生长抑素受体亚型,表达部位位于肝癌细胞的胞浆及胞膜,10例(71.4%)癌旁肝硬化组织至少表达一种受体亚型;肝癌的分化程度、TNM分期、血清AFP水平、乙肝病毒水平、肝功能Child-pugh分级等与受体的表达无明显相关性。结论72%原发性肝癌组织中表达生长抑素受体亚型SSTR2和(或)SSTR5,肝癌组织在受体的表达上存在差异性。

Objective： To investigate the expression of somatostatin receptor （SSTR） subtypes SSTR2 and SSTR5 in hepatocellular carcinoma （HCC）. Methods： The expression of SSTR was investigated in 25 samples of HCC tissue and 14 adjacent cirrhotic tissues of cancer by immunohistochemistry. Results： 18 samples（72% ） of HCC cases express SSTR2 or SSTRS, positive immunostaining for SSTR was localized primarily to the cell membrane and cytoplasm, 10 samples （71.4%） of adjacent cirrhotic tissues of cancer expressed SSTR2 or SSTRS. The corelation between SSTR expression level and human HCC differentiation, TNM stage, serum AFP level, hepatitis B virus, Child-pugh grading were not found. Conclusion： 72% HCC samples express SSTR2 or SSTRS, the expression of SSTR in HCC tissues shows variability.