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PTPN22单核苷酸多态性与类风湿关节炎关系的研究 被引量：8

Study on the relationship between polymorphism of PTPN22 and rheumatoid arthritis
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摘要 目的研究泰安地区汉族人群类风湿关节炎(rheumatoid arthritis,RA)与蛋白酪氨酸磷酸酶非受体型22(prorein tyrosine phosphatase nonreceptor 22,PTPN22)基因R620W/1858C>T多态性的相关性。方法采用PCR-RFLP技术检测128例RA患者和142例正常人PTPN22基因1858位点的基因型。结果PTPN22基因1858位点在泰安地区汉族人群仅存在C等位基因,未检测到T等位基因。结论PTPN22基因R620W多态性与泰安地区汉族人群RA的易感性无关。 Objective： To investigate the relationship between the polymorphism of PTPN22 R620W/1858C 〉 T and rhermatoid arthritis in Han nationality in Taian area. Methods： The polymorphism was analysed by polymerase chain reaction based restriction fragment length polymorphism（ PCR- RFLP） method in 128 rheumatoid arthritis patients and 142 normal control subjects. Results： Only 1858 C allele was presented in all the patients and controls, and no T allele was detected. Conclusion： There＇s no association between PTPN22 R620W and rhermatoid arthritis in Han nationality in Taian area. This suggests that the polymorphism of PTPN22 gene is associated with RA only in a specific ethnic group.
作者 柏素云 张立民 王翠香 杨志孝 张丽 方茜
机构地区 泰山医学院生化教研室 泰山医学院附属泰安医院风湿免疫科 泰山医学院分析实验室
出处 《泰山医学院学报》 CAS 2010年第2期100-102,共3页 Journal of Taishan Medical College
基金 泰安市科技计划(20074044)
关键词 蛋白酪氨酸磷酸酶非受体型22 类风湿关节炎 单核苷酸多态性 protein tyrosine phosphatase nonreceptor 22 rhermatoid arthritis single nucleotide polymorphism
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献16

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二级参考文献10

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共引文献19

同被引文献161

  • 1冯雪,李永哲.PTPN22单核苷酸多态性在自身免疫性疾病中的研究进展[J].现代免疫学,2008,28(1):79-82. 被引量：3
  • 2张志红,张学龙,陈峰,白静,傅松滨.类风湿性关节炎相关基因PTPN22 C1858T在中国6个民族中的遗传多态性研究[J].国际遗传学杂志,2007,30(2):81-84. 被引量：7
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引证文献8

二级引证文献14

泰山医学院学报
2010年 第2期

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