普罗布考对急性冠状动脉综合征患者血清髓过氧化酶和高敏C反应蛋白的影响

The effects of probucol on serum myeloperoxidase and high sensitive C-reactive protein concentrations in patients with acute coronary syndrome

目的探讨普罗布考对急性冠状动脉综合征患者血清髓过氧化酶及高敏C反应蛋白的影响及其可能机制。方法将急性冠状动脉综合征患者随机分为普罗布考组和对照组,分别检测治疗前后血清髓过氧化酶和高敏C反应蛋白的浓度。结果普罗布考组和对照组血清髓过氧化酶和高敏C反应蛋白浓度均明显下降(P<0.001);但普罗布考组较对照组血清髓过氧化酶下降更加明显(P<0.05)。结论普罗布考能降低急性冠状动脉综合征患者血清髓过氧化酶和高敏C反应蛋白水平,普罗布考更有效地降低急性冠状动脉综合征患者血清髓过氧化酶,其可能部分解释普罗布考的抗炎和抗氧化作用。

Objective： To investigate the effects of Probucol on serum myeloperoxidase （MPO） and high sensitive C-reactive protein （hs-CRP） concentrations in patients with acute coronary syndrome （ACS）. Methods： 154 patients with ACS were randomly separated into Probiacol treatment group and control group. The serum concentration of MPO and hs-CRP was measured before and after treatment. Results： Serum MPO and hs-CRP concentrations were significantly lower after treatment in the two groups （P 〈 0. 001 ）. Compared with control group serum MPO concentrations were reduced significantly in Probucol group （P 〈 0. 05 ）. Conclusion ： Probucol reduces serum MPO and hs-CRP concentrations in patients with ACS and Probucol has more significant effect in reducing the MPO in patients with ACS. These effects may explain some clinical benefits of statins in the treatment of these patients.