头孢西丁钠与注射用炎琥宁配伍稳定性考察

Compatible Stability of Cefoxitin Sodium for Injection and Potassium Sodium Dehydroandrographolide Succinate for Injection

目的:考察注射用头孢西丁钠与注射用炎琥宁在0.9%氯化钠注射液中的配伍稳定性。方法:在20℃下采用RP-HPLC法测定注射用头孢西丁钠与注射用炎琥宁在0.9%氯化钠注射液中配伍后8 h内不同时间点的含量,并观察和检测配伍液的外观及pH变化。结果:在室温下配伍液8 h内的含量、pH及外观均无明显变化。结论:注射用头孢西丁钠与注射用炎琥宁20℃在0.9%氯化钠注射液中可在配伍后8 h内使用。

Objective： To evaluate the compatible stability of the mixture of cefoxitin sodium for injection with potassium sodium dehydroandregrapholide succinate for injection in 0. 9% sodium chloride injection. Method： HPLC method was designed to study the change of content after combination of cefoxitin sodium for injection with potassium sodium dehydroandrographolide succinate in 0. 9% sodium chloride injection under the room temperature （20 ~C ） within 8 hours, and the appearance of the solution was observed and its pH value was determined. Result： No significant differences were found in the content, colour and pH value for the mixed solution de- termined at different time within 8 hours after mixing at room temperature. Concbmion： Cefoxitin sodium for injection and potassium so- dium dehydroandrographolide succinate can be mixed in 0. 9% sodium chloride injection,and used within 8 hours.