度洛西汀治疗抑郁相关疼痛障碍的随机对照研究

A random control study on treatment of depression- associated pain disorder with Dutoxetine

目的比较度洛西汀与文拉法辛治疗以疼痛为主诉的抑郁障碍的疗效和安全性。方法66例符合CCMD-3、以疼痛为主诉的抑郁障碍患者随机双盲分为度洛西汀组（33例）和文拉法辛组（33例），分别治疗8周，在治疗前及第1、2、4、6、8周末进行汉密尔顿抑郁量表（HAMD）17项、汉密尔顿焦虑量表（HAMA）和临床疗效总评量表的病情严重程度（CGI—SI）评定，及采用副反应量表（TESS）评估用药安全性，采用视觉模拟评分法（VAS）评定疼痛改善。结果治疗结束后两者疗效相比无显著性差异，但在第1、2周末两组HAMD评分差异有显著性（P〈0．05），对躯体化症状改善度洛西汀组比文拉法辛组明显。两纽不良反应均比较轻，无显著性差异。结论两组评分同样下降明显，抗抑郁、抗焦虑疗效确切，疗效相近；度洛西汀的显效快，且对躯体化症状改善明显。

Objective To compare the curative effect and safety in treating depressive disorders with pain as major symptom with Dutoxetine and Venlafaxine. Methods 66 cases of depressive patients consistent with diagnostic criteria about depressive disorders with pain as major symptom were divided into two groups in random double--blind, which include Dutoxetine （33case） and Venlafaxine groups （33case）. Patients in both groups were treated for eight weeks. The scores of Hamilton rating scale for depression （ HAMD）, Hamilton anxiety scale （HAMA） and the condition severity of clinical curative effect general comment scale （CGI--SI） were measured pre-- treatment, and 1, 2, 4, 6, and 8 weeks post--treatment. The safety of medication was assessed by treatment emergent symptom scale （TESS）. The remission of pain was evaluated by visual analogue scales （VAS）. Results There is no significant difference in the curative effect between two groups, however a significant difference is found in average scores of Hamilton rating scale for depression between two groups （P 〈 0.05）, the pain is obviously relieved in Dutoxetine group compared to Venlafaxine group. Both groups have little adverse reaction, and there is no significant difference between them. Conclusions The scores of patients in two groups de- creased obviously as well as the curative effect of antidepression and antianxiety is evident and close to each other. While Dutoxetine Sunctions quickly and relieves pain obviously compared to Venlafaxine.