摘要
目的:根据细胞色素CYP450基因多态性的分子调控、种族差异及基因多态性对药物疗效和安全性的影响等进行综述。方法:对相关细胞色素P450氧化酶的文献报道进行综合分析与评论。结果:细胞色素P450氧化酶是药物代谢的主要酶系统。人肝脏有20多个CYP450亚家族,细胞色素P450氧化酶的基因具有遗传多态性,该遗传多态性具有明显种族差异。结论:细胞色素P450氧化酶影响药物代谢动力学、药效学和临床使用安全性。
Objective： To make a review on the CYP450＇s effects on drug therapeutic outcome and safety due to its gene molecular regulation basis of its genetic polymorphism, race difference and genetic polymorphism. Methods： Internet and database literature retrieval was adopted, then comprehensive analysis and comments were made. Results： The cytochrome P450 （CYP450） oxidase is the main metabolize enzyme system in drug metabolism. There are more than 20 CYP450 subfamilies in human liver. CYP450 gene has genetic polymorphism. Its genetic polymorphism has obvious race difference. Conolusions： CYP450 oxidase affects outcomes in pharmacokinetics, pharmacodynamics and drug therapeutic safety.
出处
《药品评价》
CAS
2010年第4期58-62,共5页
Drug Evaluation
