摘要
miRNAs是一类长约21-25nt的内源性的小非编码RNA(small noncoding RNA),它在基因的转录后调控中发挥着重要的作用。miRNAs可以通过与靶基因的mRNA的3'端UTR区完全或部分互补,进而降解该目的mRNA或阻止其翻译成相关蛋白,下调靶基因表达,以此参与个体发育、细胞分化、细胞增殖以及疾病发生过程中的基因表达调控。本文简要介绍miRNAs在胰腺发育、β细胞功能以及胰腺相关疾病中的研究进展。
MiRNAs are small endogenous noncoding RNAs,about 21-25 nucleotides in length,which play important roles in posttranscriptional gene regulation.miRNAs can target mRNA with the 3 ＇-UTR perfectly or imperfectly complementary,thus the purpose of degradation of the mRNA or block its translation into proteins,downregulat gene expression.They play a crucial role in regulating development,cell differentiation,proliferation and diseases pathogenesis.In this review,we have discussed the functions of miRNAs in the pancreatic development,β-cell,diabetes and pancreatic cancer.
出处
《现代生物医学进展》
CAS
2010年第1期173-177,共5页
Progress in Modern Biomedicine
