合贝爽联合阿托伐他汀治疗不稳定型心绞痛的效果分析

Analysis on the Effect of the combined therapy of Herbesser and Atorvastatin on unstable angina pectoris

目的:分析合贝爽联合阿托伐他汀治疗不稳定型心绞痛的临床疗效,为相关治疗提供参考。方法:回顾性分析我院2007年1月至2009年6月确诊为不稳定型心绞痛而住院的患者140例,随机分为常规治疗组、合贝爽治疗组、阿托伐他汀治疗组与合贝爽联合阿托伐他汀治疗组,每组35例患者,持续用药治疗2周后,分析比较各组临床症状的缓解或消失情况。结果:合贝爽联合阿托伐他汀治疗组的心电图(ST-T改变)、早搏、心悸、胸痛、胸闷等主要症状的改善程度明显高于其他三组,差异有统计学意义,P<0.01,但其产生不良反应率偏高。结论:合贝爽联合阿托伐他汀治疗不稳定心绞痛虽可显著缓解心绞痛发作症状,但是也存在较大的副作用,用药时需要引起注意。

Objective：To analyze the clinical efficacy of the combined treatment of Herbesser and atorvastatin on unstable angina,so as to provide reference for the relevant treatment. Method：Retrospective analysis was carried on 140 cases of hospitalized patients who were diagnosed as unstable angina in our hospital from January 2007 to June 2009. Patients were randomly divided into convention-al therapy group,Herbesser treated group,atorvastatin treated group and Herbesser-combined with atorvastatin treated group,with 35 patients in each group. After two weeks of continuing medication,analysis and comparison of clinical symptoms such as mitigation or disappearance were carried between each group. Results：The improvement of ECG（ST-T changes） ,premature beat,heart palpitations,chest pain,chest tightness and other major symptoms in the Herbesser-combined with atorvastatin treated group was significantly greater than the other three groups with statistically significant differences（P0.01） ,but it caused high rate of adverse reactions. Conclusion：Although the combined treatment of Herbesser and atorvastatin on unstable angina pectoris may obviously relieve angina symptoms,it yet causes big side-effects. Attention should be paid to when medicating.