正交设计法优选甲硝唑-β-环糊精包合物制备工艺

Optimization of the Preparation Technology for the Inclusion Compound of Metronidazole-β-Cyclodextrin with an Orthogonal Test

目的:优选甲硝唑-β-环糊精包合物的制备工艺,提高甲硝唑的溶解度。方法:用饱和溶液法制备包合物,并用正交设计法优化甲硝唑-β-环糊精包合物的最佳制备条件。结果:甲硝唑-β-环糊精最佳包合条件为:甲硝唑:β-环糊精为1:2,包合时间为4h,包合温度为50℃。结论:该包合工艺可提高甲硝唑-β-环糊精包合物中甲硝唑的溶解度,工艺稳定可行。

Objective：To optimize the preparation technology for the inclusion compound of metronidazole-β-cyclodextrin and to improve its solubility. Methods：The inclusion compound was prepared with the solution method,and an orthogonal test was used to optimize the conditions for the technology of preparation. Results：The optimal conditions for the inclusion compound of the drug were：metronidazole：β-cyclodextrin = 1：2;time for inclusion ：4h;inclusion temperature：50℃. Conclusion：This inclusion technology may improve the solubility of metronidazole in the inclusion compound. The technology is feasible and stable.