颈交感神经阻滞对严重烧伤大鼠的救治作用及其机制研究

Study on the roles and mechanism of cervical sympathetic block in the treatment of severe burned rats

目的:观察颈交感神经阻滞(CSB)对严重烧伤大鼠的救治作用,并对其可能机制进行初步探讨。方法:将大鼠随机分为正常对照组、烧伤组和CSB组,烧伤组与CSB组均制作20%体表面积Ⅲ0烧伤模型,CSB组于致伤后进行颈交感神经阻滞,观察动脉血压和心率变化;测定大鼠血中皮质酮、肾上腺素浓度;观察伤后21天动物伤死情况。结果:1.颈交感神经对严重烧伤大鼠救治效果显著,烧伤组和CSB组动物21天死亡率分别为73.33%和53.33%;2.创伤后大鼠血浆内肾上腺素浓度在伤后24小时有明显上升,然后迅速下降,但是CSB组肾上腺素浓度上升幅度远远低于烧伤组;3.与正常组相比,烧伤后血清GC的水平升高非常显著,CSB治疗组虽较正常组也升高,但显著低于烧伤组。结论:颈交感神经阻滞对严重创伤动物具有明显保护效应,其保护作用机制可能与调节创伤后神经-内分泌-免疫系统功能紊乱有关。

Objective： To determine the feasibility of cervical sympathetic block （CSB） for the treatment of severer burned rats. Methods： SD rats were divided into Control, Burned and CSB groups. The roles of CSB were evaluated by comparing mortality, heart rate, blood pressure, concentrations of Glucocorticoid and Epinephrine in blood were detected. Results： Mortality in CSB group decreased significantly compared with the Burned group, CSB group kept got a better control of blood pressure. concentrations of Glucocorticoid and Epinephrine after CSB were lower than those of Burned group. Conclusion： CSB is an effective therapeutic approach for the treatment of severer burned rats. Keeping homeostatic restoration of HPA axis maybe the way to work.