青少年双生子体型指征相关指标的遗传度研究(英文)

Heritability Analysis of Body Size Indices for Adolescent Twins

目的:用经典的双生子设计探讨遗传因素对青少年身高、体重、体质指数(BMI)等体型指征的影响程度。方法:从青岛市双生子库中选择自愿参加本研究的362对11-19岁双生子,测量身高、体重。同性别的双生子通过16个多态标记进行卵型鉴定,在此基础上,应用Mx软件构建结构方程模型分析计算遗传度。结果:对362对有效双生子数据进行分析,其中同卵双生子194对,异卵双生子168对,身高的最佳拟合模型ACE模型,体重和BMI的最佳拟合模型为AE模型。调整年龄性别后,身高的遗传度为66%,体重的遗传度为84%,体质指数的遗传度为75%。结论:在青少年体型指征的相关指标中,身高、体重、BMI受遗传因素影响都较大。

Objective：To investigate the impact of inheritance on height, weight and body mass index （BMI） in adolescent by the classic twin design. Methods：362 pairs of twins aged 11-19 years old were recruited from the Qingdao Twin Registry. Height, weight were measured. Zygosity in all same-sex twin pairs was determined by 16 polymorphic markers. Heritability was assessed by structural equation models. Results：362 pairs, including 194 pairs of monozygotic twins and 168 pairs of dizygotic twins, were choosen,. The ACE model combining additive genetic and unique environmental factors was fit for height, and AE model was fit for weight and BMI. After adjusting sex and age, the heritability of height, weight and BMI were 66% , 84% and 75% respectively. Conclusion：Genes play important roles in the development of Height, Weight and BMI in adolescent .