摘要
目的探讨老年高血压病患者颈动脉粥样硬化、肱动脉内皮依赖性血管舒张功能与脑梗死发生的关系。方法100例患者分为高血压组(EH组)、脑梗死组(CI组)各50例,并与正常对照组(对照组)50例进行比较,分析血压、血脂、颈动脉内膜-中层厚度(IMT)、肱动脉内皮依赖性血管舒张(FMD)功能等变化。结果CI组表现为老年性高血压,舒张压降低明显,脉压增大;空腹血糖较对照组升高明显,但与EH组尚无显著差异;TG显著升高;CI组IMT显著增厚,斑块数及发生率显著增高,FMD下降明显。三组IMT与FMD均呈显著负相关,FMD与年龄呈负相关。结论CI组颈动脉粥样硬化程度显著增加,推测脉压增大、高TG是导致CI组患者斑块数增加引发脑梗死的直接重要危险因素。颈动脉粥样硬化、肱动脉FMD下降与脑梗死发生有密切相关性,IMT与FMD检查对预测脑梗死的发生并且对临床预防和治疗脑梗死提供重要依据。
Objective To investigate the correlation between carotid atherosclerosis,endothelium-dependent vasodilatation of brachial artery and cerebral infarction occurrence in senile hypertension patients. Methods 100 patients were divided into 50 cases of hypertension （EH group） and cerebral infarction（CI group）,which compared with 50 Patients of control grou pse parately. They were analyzed on the aspects of change in blood pressure, plasma lipids, the intima-media thickness（IMT） of carotid artery and endothelium-dependent vasodilation functiori （FMD） of brachial artery. Results Of CI group, senile high blood pressure showed up, diastolic pressure reduced distinctly and fasting blood glucose was significantly higher than the control grou pp,but there is no significant difference when compared with EH group;TG was higher and IMT were thicker markedly;Plaque block number and incidence rate was higher evidently but FMD decreased obviously. Three groups of IMT were negatively correlated with FMD,which was also negatively correlated with age. Conclusion The degree of carotid atherosclerosis significantly increased in CI group,which suggested that the increased pulse pressure and high level of TG in blood were direct and important risk factors leading to increase plaque block number which caused cerebral infarction in CI group. Carotid atherosclerosis and decreased FMD of brachial artery are closely related to cerebral infarction. The examination of IMT and FMD provided the important evidence predicting the occurrence, prevention as well as treatment of cerebral infarction.
出处
《中国现代医生》
2010年第10期8-10,共3页
China Modern Doctor
