参附注射液治疗晚期癌症患者癌因性疲乏的临床研究

Clinical study on effect of Shenfu injection treating cancer-related fatigue of patients with advanced carcinoma

目的:研究参附注射液治疗晚期癌症患者癌因性疲乏的临床疗效。方法:从2005年9月到2009年6月,选择在本院接受治疗的113例晚期癌症患者,分为实验组和对照组。实验组接受参附注射液+常规治疗,对照组仅予常规治疗。治疗3周后比较两组的癌因性疲乏程度、血红蛋白、免疫功能、心功能及血液黏度的差异。同时分析癌因性疲乏与其他观测指标的相关性。结果:实验组在缓解癌因性疲乏程度、提高血红蛋白、部分免疫指标和心功能以及降低血液黏度等方面均优于对照组。而且癌因性疲乏与血红蛋白和细胞免疫功能呈负相关,与心功能不全分级呈正相关。结论:参附注射液能通过改善晚期癌症患者的贫血状况、细胞免疫功能和心功能来有效缓解癌因性疲乏。

Objective： To study the effect of shenfu injection（SF） treating cancer-related fatigue（CRF） of the patients with advanced carcinoma. Method： From September 2005 to June 2009, selected 113 patients with advanced carcinoma who was treated in our department, and divided them into test group and control group.The test group was treated with SF and common method, while the control group only was treated with common method. Three week later, compared CRF, hemoglobin（Hb）, immune function, cardiac function and blood viscosity between the two groups. Meanwhile, analyzed the correlation between CRF and the other indicators. Result： The test group was treated more effectively than the control group in some ways, such as relieving CRF, improving hemoglobin,some immune indicators, and cardiac function, and reducing blood viscosity. Moreover, CRF had negative correlation with Hb and cell-mediated immune, and have positive correlation with cardiac disfunction degree. Conclusion： SF could relieve CRF of the patients with advanced carcinoma effectively by treating anemia and improving cell-mediated immune and cardiac function.