四君子汤加减对大肠癌术前化疗病人免疫功能的影响

Effects of Sijunzitang on Cellular Immune Functions of Colorectal Cancerous Persons with Neoadjuvant Chemotherapy

目的观察四君子汤加减对大肠癌术前新辅助化疗病人细胞免疫调节作用的影响。方法将40例大肠癌患者按治疗方案分成A组(单纯化疗组)20例,B组(化疗+四君子汤加减治疗组)20例,比较治疗前、后患者细胞免疫功能的变化。结果A、B两组CD3、CD4、NK细胞、CD4/CD8均下降,但下降幅度A组大于B组。A组CD3、CD4、NK细胞明显下降,治疗前、后对比差异有统计学意义(P<0.05);CD4/CD8亦有下降,CD8上升,但治疗前、后比较差异无统计学意义(P>0.05)。B组治疗后CD3、CD4、NK细胞及CD4/CD8亦有下降,CD8上升,但差异无统计学意义(P>0.05)。结论化疗使大肠癌患者细胞免疫功能明显下降,联合四君子汤加减治疗可望使细胞免疫功能得到改善。

Objective To observe the impact of Sijunzitang on cellular immune functions of colorectal cancerous persons with neoadjuvant chemotherapy. Methods According to different treatment regimes,40 patients were averagely divided to two groups （A group, only chemotherapy, 20;B group, chemotherapy cooperate with Sijunzitang, 20）. To compare the changes of cellular immune functions of patients at pretherapy and posttreatment. Results There are decrease of CD3,CD4,NK cell and CD4/CD8 and increase of CD8 in two groups. However, A group decline of CD3,CD4, NK cell and CD4/CD8 is greater than B group. There are significant decline of CD3,CD4,NK cell at pretherapy and posttreatment,in A group（P〈0.05）. But,the decrease of CD4/CD8 and increase of CD8 is unsatisfactory （P〉0.05）. In B group, there are also decline of CD3,CD4, NK cell and CD4/CD8, but it is unsatisfactory（P〉0.05）. Conclusion Chemotherapy can lead to a serious decline of cellular immune functions to colorectal cancerous persons, but if Sijunzitang was taken, the immune functions are hopeful to be enhanced.