一种新型介孔空腔二氧化硅纳米微球的制备与缓释行为

Fabrication and sustained release properties of porous hollow silica nanoparticles

本文用十六烷基三甲基溴化铵(CTAB)作为试剂,通过软模板法合成介孔二氧化硅,利用在合成过程中,由伪莫尔转动所引起的微粒内部的大量缺陷,通过溶剂抽提,形成了具有空腔结构的介孔二氧化硅纳米微球.采用透射电子显微镜(TEM)、X射线粉末衍射仪(XRD)、N2吸附-脱附等手段对产物的形貌和结构进行了详细的表征.并以溴甲酚绿作为目标物,通过改变压强和温度,调节溴甲酚绿进入空心SiO2微球中的不同部位,对所制备的空腔介孔二氧化硅微球进行染料的装载和释放试验.结果显示该微球腔壁具有可渗透性和缓释性,而且在负压蒸发溶剂的情况下可以得到较高的药物负载量和极大地提高缓释性能.

MCM-41-type mesoporous silica nanospheres（MSN） have been prepared using n-cetyltrimethylammonium bromide（CTAB） as a soft template.The pseudo-moire′ rotational pattern inside the MSN results in many interior defects.Hollow mesoporous silica（HMS） spheres were synthesized by solvent extraction of the template from MSN.The morphology and structure of MSN and HMS were studied by TEM,XRD and nitrogen sorption techniques.A model drug,bromocresol green dye,was packed inside different regions of HMS through impregnation at different pressures and temperatures,and the drug release performance of the resulting materials was compared.The results showed that vacuum evaporation of solvent can greatly enhance the controlled release properties.