乙肝病人胃十二指肠粘膜HBsAg、HBcAg与胃部病变、血清HBVM的关系研究

STUDY OF RELATIONSHIP BETWEEN HBsAg AND HBcAg IN GASTRONDUODENAL MUCOSA SPECIMENS AND GASTRONDUODENAL PATHOLOGIC CHANGES AND HBVM OF SERUM WITH HEPATITS B PATIENTS

目的：研究乙肝病毒与胃十二指肠粘膜病变及血清HBVM的关系。方法：应用HE染色、SP兔疫组化法检测63例乙肝病人胃十二指肠粘膜的HBsAg、HBcAg；应用酶标法检测其血清HBsAg、HBcAg，地高辛探针法检测HBV－DNA。结果：63例乙肝病人胃十二指肠粘膜均有不同程度的病理改变，以慢性浅表性胃炎多见，其次为溃疡病；胃十二指肠粘膜单项HB－sAg阳性率约31．7％，单项HBcAg阳性率约22．2％，一项以上阳性率约42．9％；胃十二指肠粘膜HBVM与病变程度有关，与血清相应的HBVM、HBV-DNA无关。结论：HBV可侵犯胃十二指肠粘膜，可能发生原位复制引发病理损伤。胃十二指肠粘膜HBsAg、HBcAg检测可作为判断HBV在体内复制、分布状态的新指标。

Objective: To study the relationship between HBV and gastronduodenal mucosa pathologic changes and HBVM of serum. Methods: The gastronduodenal mucosa specimens of 63 patients with hepatitis B were made by HE staining and HBsAg, HBcAg immunohistochemical methods. Results: All gastronduodenal mucosa of 63 hepatitis B patients had pathologic changes in various degrees with 31. 7% of single HBsAg positive,22. 2 % of single HBcAg positive, and 42. 9 % of two or more items positive. Muscoa HBVM was related to gastronduodenal pathologic changes but not related to the corresponding HBVM and HBV-DNA of the serum. Conclusions: It is suggested that HBV can invade gastronduodenal mucosa and replicate in the site, resulting in pathologic changes. The detection of HBsAg, HBcAg in gastronduodenal mucosa can be regarded as a new mark of judging HBV replication and distribution in body.