米非司酮治疗子宫内膜异位症的临床研究

CLINICAL OBSERVATION ON TREATMENT OF ENDOMETRIOSIS WITH MIFEPRISTONE (Ru486)

目的：评价米非司酮治疗子宫内膜异位症及子宫腺肌症的效果及安全性。方法：用米非司酮25mg，每日1次，口服，连续3个月，治疗16例子宫内膜异位症及腺肌症病人，观察临床症状的变化，治疗前后进行B超及血性激素检查。结果：所有病人痛经及盆腔痛症状消失，血性激素显示孕酮（P4）下降，促黄体素（LH）升高，未出现明显副作用。结论：米非司酮治疗子宫内膜异位症能明显改善病人症状，是安全有效的。

Objective: To evaluate the safety and effect of mifepristone (Ru486) on patients with endometriosis. Methods: Sixteen consecutive patients with pelvic endqmetriosis and adenomyosis were given Ru486 25 mg/d for 3 months. Clinical symptoms were observed, blood sexal hormene analysed and B-mode sonography examined before and after the treatment. Result: All the patients became amenorrhea and their dysmenorrhea and pelivic pain were relieved during the treatment. The sexal hormone measurment showed LH increased and P decreased. No significant side effect was obserred. Conclusion: Administration of Ru486 in patients with endometrlosis can safely and effectively relieve the symptoms