期刊文献+

不同类型脑梗死后凝血及纤溶功能的改变 被引量:4

Changes of coagulation and fibrinolysis functions following different subtypes of brain infarction
下载PDF
导出
摘要 目的研究不同类型脑梗死后凝血及纤溶系统不同的连续改变。方法发病48h内的脑梗死患者136例,分为心源性栓塞性脑梗死(CEI)组(45例)、动脉粥样硬化血栓形成性脑梗死(ATI)组(39例)及腔隙性脑梗死(LI)组(52例),以同期年龄、性别匹配的非脑血管病患者为对照组(38例)。测定脑梗死患者发病后48h内、1周及3周时血浆中凝血酶-抗凝血酶Ⅲ复合物(TAT)、纤维蛋白肽A(FpA)和D-二聚体水平。结果CEI组患者发病后48h内、1周及3周时血浆中TAT、FpA和D-二聚体水平均显著高于对照组(P值分别<0.01、0.05)。ATI组患者发病后48h内及1周时血浆中TAT和FpA水平显著高于对照组(P值分别<0.01、0.05),发病后1周及3周时血浆中D-二聚体水平显著高于对照组(P值分别<0.01、0.05)。LI组患者不同时间各指标与对照组的差异均无统计学意义(P值均>0.05)。结论不同类型脑梗死后凝血及纤溶系统的改变是不同的,从而为明确脑梗死的发病机制提供一些线索。 Objective To study the changes of coagulation and fibrinolytic functions after different types of cerebral infarctions.Methods A total of 136 patients within 48 h of acute ischemic stroke were included in the present study,and they were divided into three subgroups,including 45 with acute cardioembolic infarction(CEI),39 with atherothrombotic infarction(ATI),and 52 with lacunar infarction(LI).Thirty-eight age-and sex-matched non-cerebral vascular patients,who were treated in our hospital during the same period,were taken as controls.The plasma levels of thrombin-antithrombin Ⅲ complex(TAT),fibrinopeptide A(FpA) and D-dimer were measured within 48 h,at 1 week,and 3 weeks after the stroke onset.Results The levels of plasma TAT,FpA and D-dimer in the CEI group were significantly higher than those in the control group(P〈0.05,0.01).The levels of plasma TAT and FpA within 48 h and at 1 week in ATI group were significantly higher than those in the control group(P〈0.05,0.01);the level of D-dimer was significantly higher than that in the control group at 1 week and 3 weeks after stroke onset(P〈0.05,0.01).There were no significant differences in the above parameters between the LI group and the control group at all defined time points(P〉0.05).Conclusion Our findings suggest that the changes of coagulation and fibrinolysis are different in patients with different subtypes of cerebral infarctions,which may cast new lights on the mechanism of cerebral infarction.
出处 《上海医学》 CAS CSCD 北大核心 2010年第1期55-58,共4页 Shanghai Medical Journal
基金 上海市卫生局科技发展基金资助项目(054011)
关键词 凝血标志物 脑梗死 血栓形成 纤溶 Coagulation markers Brain infarction Thrombosis Fibrinolysis
  • 相关文献

参考文献26

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33008
  • 2Special report from the National Institute of Neurological Disorders and Stroke. Classification of cerebrovascular diseases Ⅲ. Stroke, 1990, 21: 637-676.
  • 3Ramirez-Lassepas M, Cipolle R J, Bjork R J, et al. Can embolic stroke be diagnosed on the basis of neurologic clinical criteria? Arch Neurol, 1987, 44: 87-89.
  • 4Kittner S J, Sharkness C M, Price T R, et al. Infarcts with a cardiac source of embolism in the NINCDS Stroke Data Bank: historical features. Neurology, 1990, 40: 281-284.
  • 5Altes A, Abellan M T, Mateo J, et al. Hemostatic disturbances in acute ischemic stroke: a study of 86 patients. Acta Haematol, 1995, 94:10-15.
  • 6Fon E A, Mackey A, Cote R, et al. Hemostatic markers in acute transient ischemic attacks. Stroke, 1994, 25:282-286.
  • 7Sloan M A. Thrombolysis and stroke. Past and future. Arch Neurol, 1987, 44: 748-768.
  • 8Wada H, Sakuragawa N, Mori Y, et al. Hemostatic molecular markers before the onset of disseminated intravascular coagulation. Am J Hematol, 1999, 60: 273- 278.
  • 9Ince B, Bayram C, Harmanci H, et al. Hemostatic markers in ischemic stroke of undetermined etiology. Thromb Res, 1999, 96:169-174.
  • 10Feinberg W M, Bruck D C, Ring M E, et al. Hemostatie markers in acute stroke. Stroke, 1989, 20: 592-597.

二级参考文献13

  • 1谢瑞芹,王凤飞,都本洁,都军,张玉华,李荣华.凝血纤溶指标的变化与缺血性心脏病的关系[J].中国介入心脏病学杂志,1997,5(1):23-25. 被引量:12
  • 2Eriksson BI, lassen MR. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery.Arch Intern Med,2003,163:1337-1342.
  • 3Ollendorf DA, Vera-Llonch M, Oster G. Cost of venous thromboembolism following major orthopaedic surgery in hospitalized patients. Am J Health Syst Pharm, 2002,59:1750-1754.
  • 4Lopez Y, Paloma MJ, Rifon J ,et al. Measurement of prethrombotic markers in the assessment of acquired hypercoagulable states. Thromb Res, 1999,93: 71-78.
  • 5Perrier A, Desmarais S, Miron MJ, et al. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet , 1999,353:190-195.
  • 6Owings JT, Gosselin RC, Anderson JT, et al. Practical utility of the D-dimer assay for excluding thromboembolism in severely injured trauma patients. J Trauma,2001,51:425-430.
  • 7Michiels JJ,Schroyens W, De Backer W,et al. Non-invasive exclusion and diagnosis of pulmonary embolism by sequential use of the rapid ELISA D-dimer assay, clinical score and spiral CT. Int Angiol, 2003,22:1-14.
  • 8Perez JV, Warwick DJ, Case CP,et al. Death after proximal femoral fracture: an autopsy study. Injury, 1995,26: 237-240.
  • 9Britt LD, Zolfaghari D, Kennedy E, et al. Incidence and prophylaxis of deep vein thrombosis in a high risk trauma population.Am J Surg,1996,172: 13-14.
  • 10Ennis RS. Postoperative deep vein thrombosis prophylaxis: a retrospective analysis in 1000 consecutive hip fracture patients treated in a community hospital setting. J South Orthop Assoc, 2003,12: 10-17.

共引文献33017

同被引文献65

引证文献4

二级引证文献99

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部