支气管哮喘急性发作期患者血浆内皮素水平的变化

The Change of Plasma Level of Endothelin in Patients with Acute Attack of Asthma

为探讨内皮素（ＥＴ）与支气管哮喘急性发作的相互关系，采用放射免疫分析法对２３例支气管哮喘急性发作期患者和１２例正常人血浆ＥＴ水平进行检测，并与动脉血氧分压（ＰａＯ２）和最大呼气流量（ＰＥＦ）进行相关分析。结果发现哮喘急性发作期患者血浆ＥＴ水平为８９．２±８．４ｎｇ／Ｌ，明显高于正常组的５２．２±６．５ｎｇ／Ｌ（Ｐ＜０．００１）；且ＥＴ水平与ＰａＯ２和ＰＥＦ呈明显负相关（ｒ分别为－０．７８９３和－０．７１２４，Ｐ＜０．０１）。提示ＥＴ可能与哮喘患者的急性发作有一定的关系，并可反映病情的严重程度。

In order to assess the interaction of endothelin (ET) and acute attack of asthma, the plasma levels of ET in 23 patients with acute attack of asthma and 12 normal controls were measured by radioimmunoassay. The partial pressure of oxygen in arterial blood(PaO 2) and peak flow (PEF) were measured synchronously. The results showed that the plasma ET level in asthmatic patients (89 2±8 4ng/L) was much higher than that in normal controls (52 2±6 5ng/L), P <0 001. There was a significant negative correlation between the plasma level of ET and the PaO 2( r =-0 7893, P <0 01) or PEF( r = -0 7124, P <0 01). The results suggest that ET may play a role in acute attack of asthma, and its level may stand for the degree of the disease.