载硒酵母对小鼠化学性肝损伤的影响

The effects of selenium-enriched yeast on chemical liver injury in mice

观察不同剂量（３０，６０，９０ｍｇ／ｋｇ）载硒酵母（ｓｅｌｍｉｎｍ－ｅｎｒｉｃｈｅｄｙｅａｓｔ，ＳＥＹ）ｉｇ７天对ＣＣｌ４和Ｄ－Ｇａｌ－Ｎ引起的化学性肝损伤的保护作用。结果发现：ＳＥＹ６０ｍｇ／ｋｇ可降低ＣＣｌ４所致血清ＡＬＴ的升高，各剂量组均可降低Ｄ－Ｇａｌ－Ｎ所致血清ＡＬＴ和ＡＳＴ的升高，ＳＥＹ３０ｍｇ／ｋｇ可减轻Ｄ－Ｇａｌ－Ｎ所致肝病理损伤，各剂量组ＳＥＹ均可降低Ｄ－Ｇａｌ－Ｎ所致肝匀浆ＭＤＡ含量升高。提示ＳＥＹ在一定程度上可减轻ＣＣｌ４和Ｄ－Ｇａｌ－Ｎ的化学性损伤，其作用机制可能与抗氧化作用有关。

To observe the protective effect of selenium enriched yeast(SEY)with different ig dose(30,60,90 mg/kg)for 7d on chemical liver injury produced by CCl 4 and D-Gal-N.the result showed that elevation of ALT in serum produced by CCl 4 was decreased by SEY at a dose of 60 mg/kg,the elevation of ALT and AST in serum produced by D-Gal-N was decreased by SEY of all dosage groups,the liver damage in pathological examination was reduced by SEY at a dose of 30 mg/kg,and the elevation of molondialdehyde(MDA)contents in hepatic homogeneization produced by D-Gal-N was decreased by SEY of all dosage groups.It indicated that SEY moderately prevent the liver injury produced by CCl 4 and D-Gal-N.Its mechanism can related with the effects of antioxidation.