急性胰腺炎患者血清降钙素原检测及其临床意义

Serum Procalcitonin in Patients with Aacute Pancreatitis and its Clinical Significance

目的探讨急性胰腺炎(AP)患者血清降钙素原(PCT)水平变化及其意义。方法41例AP患者分为水肿型组(23例)和出血坏死型组(18例),采用双抗体夹心法测定其入院当天及综合治疗1周后血清PCT,并与正常对照组20例进行比较。结果入院时水肿型组和出血坏死型组血清PCT水平明显高于对照组(均P<0.05);出血坏死型组血清PCT水平明显高于水肿型组(P<0.05);治疗后出血坏死型组血清PCT水平明显高于水肿型组及对照组(均P<0.05),而水肿型组血清PCT水平接近正常,显著低于入院时水平(P<0.05)。结论PCT可以作为AP的早期诊断和判断预后的指标。

Objective To investigate the acute pancreatitis （AP） serum procalcitonin （PCT） levels and their significance. Methods 41 cases of AP patients were divided into edematous group （23 cases）, and hemorrhagic necrotic type group （18 cases）, using double-antibody sandwich method were determined the day of admission and the week after the combined treatment of serum PCT, and 20 cases with normal control group to compare. Results Admission group and the hemorrhagic necrosis of edematous type serum PCT levels were significantly higher （all P〈0.05）; hemorrhagic necrotic type serum PCT levels were significantly higher than the edematous group （P〈0.05）; hemorrhagic necrosis after treatment Type serum PCT levels were significantly higher than the edematous group and control group （all P〈0.05）,Yhe edematous near normal levels of serum PCT was significantly lower than the level on admission （P〈0.05）. Conclusion PCT can be used as AP of early diagnosis and prognosis indicators.