龙胆酒炙前后整体化学成分变化研究

Study of the Chemical Changes in the Preparing Process of Longdan

为了研究龙胆酒炙前后化学成分的整体变化,寻求炮制增效,改变药性及减毒的物质基础,揭示炮制机理。取龙胆生品和酒炙品,分别用甲醇和水提取。将提取液进行高效液相色谱分析。比较龙胆生品和酒炙品醇提液和水煎液的色谱图。经仔细核对各色谱图,结合紫外光谱分析,发现酒炙品中化学成分确实发生了量的和质的变化。研究表明,龙胆酒炙品药性的显著变化正是其化学成分整体变化所导致的,有效成分溶出增加,药效增强。

OBJECTIVE：Study the chemical changes in the preparing process of Longdan, in order to reveal the mechanism of increasing effectiveness and detoxication in the preparing process. METHODS： Extract the raw and prepared Longdan with water and methanol, then analyze with HPLC respectively. RESULTS： There are obvious chemical changes in the perpared drugs through comparing the chromatogramso CONCLUSIONS： The changes of characteristics of Longdan are because of its chemical changes in the preparing process.